Author/Authors :
Hai-Feng Cui، نويسنده , , Peng Li، نويسنده , , Xiao-Wei Wang، نويسنده , , Zhuo Chai، نويسنده , , Ying-Quan Yang، نويسنده , , Yue-Peng Cai، نويسنده , , Shizheng Zhu، نويسنده , , Gang Zhao، نويسنده ,
Abstract :
Primary amines catalyzed the asymmetric Michael addition of ethyl 2-fluoro-2-nitroacetate to enones to provide chiral α-fluoro-α-nitro ester ketones with two contiguous stereogenic centers, one of which is a fluorinated quaternary chiral center, with excellent enantioselectivities and in moderate to good yields.
Keywords :
Primary amine , Asymmetric Michael addition , Fluorinated , enantioselectivities
