Title of article :
Regioselective synthesis of 1,3,5- and 1,3,4,5-substituted pyrazoles via acylation of N-Boc-N-substituted hydrazones
Author/Authors :
Alessandro Tinarelli، نويسنده , , Paolo Righi، نويسنده , , Goffredo Rosini، نويسنده , , Daniele Andreotti، نويسنده , , Roberto Profeta، نويسنده , , Simone Spada، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
Acylation of N-Boc-N-methylhydrazones followed by TFA treatment affords regioselective access to substituted pyrazoles. Both regioisomers of 1-methyl-3,5-disubstituted-1H-pyrazoles can be selectively obtained. This procedure can also be employed for the regioselective preparation of fully substituted 1H-pyrazoles.
Keywords :
N-Boc-N-methylhydrazone acylation , 5-Trisubstituted pyrazoles , 1 , 3 , 4 , 1 , 5-Tetrasubstituted pyrazoles , Regioselective pyrazole synthesis , 3
Journal title :
Tetrahedron
Journal title :
Tetrahedron
