Solvent controlled regioselective reaction of 1,2,3-benzotriazole (BtH) with pentafluorobenzene derivatives

Regioselective reaction of 1,2,3-benzotriazole (BtH) with pentafluorobenzene derivatives under base conditions was investigated and its regioselectivity strongly depends on solvent, base, and electron-withdrawing group at 4-position on the perfluorophenyl ring. Several Bt(N1)-substituted perfluorobenzenes were prepared by using this method.