Author/Authors :
Jian-Fan Sun، نويسنده , , Hui Huang، نويسنده , , Xing-Yun Chai، نويسنده , , Xian-Wen Yang، نويسنده , , Li Meng، نويسنده , , Cai-Guo Huang، نويسنده , , Xue-Feng Zhou، نويسنده , , Bin Yang، نويسنده , , Jing Hu، نويسنده , , Xian-Qiang Chen، نويسنده , , Hui Lei، نويسنده , , Lishu Wang، نويسنده , , Yonghong Liu، نويسنده ,
Abstract :
Five new briarane type diterpenoids, dichotellides A−E (1−5), were isolated from the South China Sea gorgonian Dichotella gemmacea together with four known analogues (6−9). Compounds 1−5 represent the first examples of iodine-containing briarane type diterpenoids from nature. The structures of these diterpenoids were elucidated by spectroscopic analysis, including 1D, 2D-NMR, and HRESIMS, and the absolute configuration of 1 was further confirmed by single crystal X-ray diffraction analysis. All the isolates were evaluated for cytotoxicity activity against four human tumor cell lines, and only 3 exhibited marginal activity against SW1990 (human pancreatic cancer).
Keywords :
X-ray diffraction , Cytotoxicity , gorgonian , Dichotella gemmacea , Dichotellides , Iodine-containing briarane type diterpenoid
