Title of article :
A New Synthesis of 4-Dialkylamino-1,5-dihydropyrrol-2-ones by PdCatalyzed Oxidative Aminocarbonylation of 2-Ynylamines
Author/Authors :
Gabriele، Bartolo نويسنده , , Salerno، Giuseppe نويسنده , , Costa، Mirco نويسنده , , Plastina، Pierluigi نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A novel synthesis of (gamma)-lactam derivatives 4 is reported, based on PdI2catalyzed oxidative monoaminocarbonylation of 2-ynylamines, followed by in situ conjugate addition of a secondary amine and lactamization. Tetramic acids can be easily obtained from 4 by acid-catalyzed hydrolysis at room temperature.
Keywords :
aminocarbonylation , Tetramic acids , Palladium , (gamma)-lactams , Carbonylation
