Author/Authors :
Haifeng Wang ، نويسنده , , Peng Li، نويسنده , , Hai-Feng Cui، نويسنده , , Xiao-Wei Wang، نويسنده , , Jun-Kang Zhang، نويسنده , , Wen Liu، نويسنده , , Gang Zhao، نويسنده ,
Abstract :
The enantioselective Michael addition of α-cyanoketones to α,β-unsaturated trichloromethyl ketones was firstly reported. With a phenylalanine-derived bifunctional piperazine/thiourea catalyst, a series of α-trichloromethyldihydropyrans were obtained with up to 95% ee and 99% yield.
Keywords :
Trichloromethyl ketones , Dihydropyrans , Bifunctional organocatalysts , Michael addition , Enantioselectivity
