Author/Authors :
Yue Huang، نويسنده , , Lijun Ni، نويسنده , , Haifeng Gan، نويسنده , , Yu He، نويسنده , , Jinyi Xu، نويسنده , , Xiaoming Wu، نويسنده , , Hequan Yao، نويسنده ,
Abstract :
A facile and environment-benign oxidation by dioxygen as the sole oxidant was applied for the conversion of 2-oxazolines to oxazoles. The substituent effect on 2-oxazoline ring was investigated. The use of this methodology for the synthesis of a key intermediate of a CDC25 phosphatase inhibitor (SC-ααδ9) as an anticancer agent was also described.
Keywords :
2-Oxazolines , oxazoles , Dioxygen , Environmental-benign , Oxidation
