Title of article
Synthesis of gemini triethylene-tetramine bridged bis-tridentate iron(III) chelators
Author/Authors
David Rodriguez-Lucena، نويسنده , , Isabelle J. Schalk، نويسنده , , Gaëtan L.A. Mislin، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
6
From page
2149
To page
2154
Abstract
Eight gemini bis-2-(2-hydroxyphenyl)-thiazole-4-carboxamide and -thiocarboxamide (BHPTC) chelators were efficiently synthesized. Mass spectrometry showed these compounds all form 1:1 complexes with iron(III). Three of these chelators exhibit promising antiproliferative activities when tested on human cancerous cell lines.
Keywords
Cancer , Iron chelation therapy , Triethylene-tetramine , Iron chelator , BHPTC , Thioamide
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103048
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