Title of article :
Palladium catalyzed stereoselective synthesis of 3-(anilinoarylmethylene)-2-oxindoles as Hesperadin analogoues
Author/Authors :
Morteza Bararjanian، نويسنده , , Saeedeh Hosseinzadeh، نويسنده , , Saeed Balalaie، نويسنده , , Hamid Reza Bijanzadeh، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
Potentially bioactive 3-(anilinoarylmethylene)-2-oxindoles as Hesperadin analogoues have been synthesized via a two-step procedure: (a) an Ugi-4MCR and (b) reaction of the Ugi adduct with aniline in the presence of a palladium catalyst via domino Heck/Buchwald reaction. In all cases, a single isomer with the Z-configuration was obtained in good to high yields.
Keywords :
Stereoselective synthesis , Hesperadin , Ugi-4MCR , Domino Heck/Buchwald reaction , 3-(Aminomethylene)-2-oxindoles
Journal title :
Tetrahedron
Journal title :
Tetrahedron
