Title of article :
Synthesis of polysubstituted 5-aminopyrimidines from α-azidovinyl ketones and amidines
Author/Authors :
Miao Hu، نويسنده , , Jianwei Wu and Mulin Liu، نويسنده , , Yaohong Zhang، نويسنده , , Fangli Qiu، نويسنده , , Yongping Yu، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
A simple and direct synthesis of polysubstituted 5-aminopyrimidines from α-azidovinyl ketones and amidines in the present of base was developed. The reactions were performed under mild conditions in good to excellent yields. Additionally a possible mechanism of 1,4-Michael addition is proposed.
Keywords :
Amidines , Polysubstituted 5-aminopyrimidines , 4-Michael addition , rearrangement , ?-Azidovinyl ketones , 1
Journal title :
Tetrahedron
Journal title :
Tetrahedron
