Author/Authors :
Ruonan Zhang، نويسنده , , Maged George Iskander، نويسنده , , Pedro Paulo da Silva Soares، نويسنده , , Daniel Chan، نويسنده , , Valentina Vignevich، نويسنده , , Vi Nguyen، نويسنده , , Mohan M. Bhadbhade، نويسنده , , David StC Black، نويسنده , , Naresh Kumar، نويسنده ,
Abstract :
A series of novel 5-arylidenefuran-2(5H)-ones and 5-arylidene-4-arylfuran-2(5H)-ones were synthesized via the Suzuki–Miyaura reactions of fimbrolide derivatives 5-(bromomethylene)furan-2(5H)-one and 4-bromo-5-(bromomethylene)furan-2(5H)-one, respectively. A regioselective Suzuki–Miyaura reaction on 4-bromo-5-(bromomethylene)furan-2(5H)-one allowed the synthesis of unsymmetrically substituted 5-arylidene-4-arylfuran-2(5H)-ones. The crystal structure of the intermediate 5-arylidene-4-bromofuran-2(5H)-one revealed interesting Br⋯O halogen bonding.
Keywords :
Fimbrolide , Antibacterial , Furanone , Suzuki–Miyaura
