Title of article
Diastereoselective Mukaiyama aldol reaction of (N-alkyl) isatins with 2-(trimethylsilyloxy)furan by using lanthanum triflate
Author/Authors
Harshadas Mitaram Meshram، نويسنده , , Palakuri Ramesh، نويسنده , , Bandi Chennakesava Reddy، نويسنده , , Balasubramanian Sridhar، نويسنده , , Jhillu Singh Yadav، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
6
From page
3150
To page
3155
Abstract
An efficient vinylogous Mukaiyama aldol reaction (VMAR) of 2-(trimethylsilyloxy)furan with various (N-alkyl)isatins is described in the presence of lanthanum(III) triflates (5 mol %). The reaction proceeds rapidly and affords the corresponding 3-hydroxy-(5-oxo-2,5-dihydrofuran-2-yl)indolin-2-one in high yields with good diastereoselectivities (threo:erythro ratio up to ≤95:5).
Keywords
Isatins , Mukaiyama aldol reaction , 2-(trimethylsilyloxy)furan , La(OTf)3
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103162
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