Author/Authors :
Sheng Ouyang، نويسنده , , Lei Wang، نويسنده , , Qingwen Zhang، نويسنده , , Guocai Wang ، نويسنده , , Ying Wang، نويسنده , , Xiaojun Huang and Xiaodong Yuan، نويسنده , , Xiaoqi Zhang، نويسنده , , Ren-Wang Jiang، نويسنده , , Xinsheng Yao، نويسنده , , Chun-Tao Che، نويسنده , , Wen-Cai Ye، نويسنده ,
Abstract :
Six new monoterpenoid indole alkaloids along with four known analogues were isolated from the aerial part of Gelsemium elegans. Their structures with absolute configurations were elucidated by NMR, HRESIMS, X-ray diffraction, CD spectra, and molecular modeling calculation. Among them, gelselenidine (1) is a new gelsedine-type alkaloid with a 2,3-epoxybutane unit. Gelseziridine (2) is the first example of monoterpenoid indole alkaloids with an oxaziridine residue. Compounds 6 and 7 are a pair of N4 epimers of humantenine N4-oxide. A plausible biogenetic pathway for compounds 1–4 was also proposed.
Keywords :
Gelselenidine , Gelseziridine , Monoterpenoid alkaloid , Gelsemium elagans , oxindole alkaloid
