Title of article :
Effect of Water on Keck’s Catalytic Asymmetric Allylations of Aldehydes
Author/Authors :
Kurosu، Michio نويسنده , , Lorca، Miguel نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The complex generated from BINOL, Ti(i-PrO)4, and unactivated or a large amount of activated 4 (ANGESTROM) MS in toluene is very effective in catalytic allylations of aldehydes using allyltributyltin. Allylations with 2.5 mol% of the catalyst provide homoallylic alcohols with greater than 95% ee. Very high syn-selective allylations of protected b-hydroxyaldehydes are achieved with 5 mol% of the BINOL/Ti(i-PrO)4 complex.
Keywords :
allyltributyltin , Ti(i-PrO)4 , catalytic asymmetric allylation , 4 A molecular sieves , BINOL
