Title of article :
A novel and practical synthetic route for the total synthesis of lycopene
Author/Authors :
Runpu Shen، نويسنده , , Xiaoyue Jiang، نويسنده , , Weidong Ye، نويسنده , , Xiaohua Song، نويسنده , , Luo Liu، نويسنده , , Xuejun Lao، نويسنده , , Chunlei Wu، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Pages :
5
From page :
5610
To page :
5614
Abstract :
A novel route for the total synthesis of lycopene 1 is described. The synthesis is based on: (i) a condensation between 4,4-dimethoxy-3-methylbutanal 4 and methylenebisphosphonic acid tetraethyl ester 5, leading to the C6-phosphonate 6, followed by (ii) a modified Wittig–Horner reaction between 6 and 6-methyl-5-hepten-2-one 7 producing dimethoxy-3,5,9-triene 8, and (iii) another modified Wittig–Horner reaction between C15-phosphonate 2 and C10-triene dialdehyde 3 producing all-E-lycopene. The synthetic steps are easily operated and practical for the large-scale production.
Keywords :
Total synthesis , Wittig–Horner reaction , Lycopene
Journal title :
Tetrahedron
Serial Year :
2011
Journal title :
Tetrahedron
Record number :
1103474
Link To Document :
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