Title of article :
An expeditious approach to 1-(isoquinolin-1-yl)guanidines via a three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, with carbodiimide
Author/Authors :
Huanhuan Wang، نويسنده , , Shengqing Ye، نويسنده , , Hanpeng Jin، نويسنده , , Jianping Liu، نويسنده , , Jie Wu، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
A small library of 1-(isoquinolin-1-yl)guanidine is constructed efficiently via a silver triflate-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, with carbodiimide. The preliminary biological screens of these isoquinoline library members have been evaluated, which show promising results as PTP1B inhibitor and HCT-116 inhibitor.
Keywords :
2-Alkynylbenzaldehyde , Carbodiimide , 1-(Isoquinolin-1-yl)guanidine , Sulfonohydrazide , silver triflate
Journal title :
Tetrahedron
Journal title :
Tetrahedron
