Title of article :
Highly stereoselective titanium-mediated aldol reactions from chiral α-silyloxy ketones. A reliable tool for the synthesis of natural products
Author/Authors :
Judit Esteve، نويسنده , , Carme Jiménez، نويسنده , , Joaquim Nebot، نويسنده , , Javier Velasco-Martin، نويسنده , , Pedro Romea، نويسنده , , Fèlix Urp?، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
Chiral α-silyloxy ketones participate in highly stereoselective TiCl4-mediated aldol reactions that afford diastereomerically pure syn–syn adducts in high yield irrespective of the R1 and R2 substituents flanking the carbonyl or the silicon protecting group. Further manipulation of the resulting aldol adducts provide in a straightforward manner highly functionalized fragments that facilitate the synthesis of natural products.
Keywords :
Aldol reactions , natural product synthesis , Chiral ketones , Stereoselective reactions , Titanium enolates
Journal title :
Tetrahedron
Journal title :
Tetrahedron