Title of article :
Dynamic resolution of α-halo chiral esters for the synthesis of 3-substituted piperazin-2-ones
Author/Authors :
Jung In Jang، نويسنده , , Seock-Yong Kang، نويسنده , , Kyoung Hee Kang، نويسنده , , Yong-Sun Park and Sang Joon Kim، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
Dynamic resolution of α-halo esters derived from five chiral alcohols has been investigated in nucleophilic substitution with ethylenediamine nucleophiles. Stereoselective substitution of α-halo esters and following spontaneous cyclization provide a practical protocol for asymmetric syntheses of 3-substituted piperazin-2-ones up to 94:6 er.
Keywords :
Asymmetric synthesis , Dynamic resolution , Nucleophilic substitution , Piperazinone , Chiral auxiliary
Journal title :
Tetrahedron
Journal title :
Tetrahedron
