Title of article
Dynamic resolution of α-halo chiral esters for the synthesis of 3-substituted piperazin-2-ones
Author/Authors
Jung In Jang، نويسنده , , Seock-Yong Kang، نويسنده , , Kyoung Hee Kang، نويسنده , , Yong-Sun Park and Sang Joon Kim، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
6
From page
6221
To page
6226
Abstract
Dynamic resolution of α-halo esters derived from five chiral alcohols has been investigated in nucleophilic substitution with ethylenediamine nucleophiles. Stereoselective substitution of α-halo esters and following spontaneous cyclization provide a practical protocol for asymmetric syntheses of 3-substituted piperazin-2-ones up to 94:6 er.
Keywords
Asymmetric synthesis , Dynamic resolution , Nucleophilic substitution , Piperazinone , Chiral auxiliary
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103546
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