Author/Authors :
Mihoko Mori، نويسنده , , Hiromi Morimoto، نويسنده , , Yong Pil Kim، نويسنده , , Hideaki Ui، نويسنده , , Kenichi Nonaka، نويسنده , , Rokuro Masuma، نويسنده , , Kimitoshi Sakamoto، نويسنده , , Kiyoshi Kita، نويسنده , , Hiroshi Tomoda، نويسنده , , Kazuro Shiomi، نويسنده , , Satoshi Omura، نويسنده ,
Abstract :
Screening for NADH-fumarate reductase inhibitors led to the isolation of the new polyketide compounds, ukulactones A and B (1 and 2, ) from a culture broth of Penicillium sp. FKI-3389. The structure of ukulactone A was elucidated as a methylated derivative of prugosene A1, which was produced by Penicillium rugulosum and NOESY experiment revealed ukulactone B was a stereoisomer of ukulactone A. Ukulactone A showed potent inhibitory activity against NADH-fumarate reductase of the roundworm Ascaris suum in vitro.
Keywords :
Electron transport enzyme inhibitor , NADH-fumarate reductase , Penicillium , Ukulactone
