Author/Authors :
Graziella Cappelletti، نويسنده , , Daniele Cartelli، نويسنده , , Bruno Peretto، نويسنده , , Micol Ventura، نويسنده , , Marco Riccioli، نويسنده , , Francesco Colombo، نويسنده , , John S. Snaith، نويسنده , , Stella Borrelli، نويسنده , , Daniele Passarella، نويسنده ,
Abstract :
The use of tubulin as a target to influence the composition of the mixture from a dynamic combinatorial library, based on the disulfide bond exchange reaction, is described. ESI-FT-ICR-MS was used to determine the composition of the library. The heterodimeric compound amplified by this approach was used to design the homologous derivative with a two-carbon spacer in place of the disulfide function. The ability of the compounds to inhibit tubulin polymerization is reported and compared to thiocolchicine.
