Author/Authors :
Miki Ito، نويسنده , , Fujiko Konno، نويسنده , , Takuya Kumamoto، نويسنده , , Noriyuki Suzuki، نويسنده , , Masatoshi Kawahata، نويسنده , , Kentaro Yamaguchi، نويسنده , , Tsutomu Ishikawa، نويسنده ,
Abstract :
Both enantiomers of chelidonine, a B/C-cis-11-hydroxyhexahydrobenzo[c]phenanthridine alkaloid, were synthesized by manipulation of the B/C-dehydro ring juncture of benzo[c]phenanthridine skeleton using Sharpless asymmetric dihydroxylation and stereospecific catalytic hydrogenation after introduction of oxygen functions on the C ring as key reaction steps for the construction of stereogenic centers.
