Title of article :
Efficient Enantioselective Formal Synthesis of Ro 67-8867, a NMDA 2B Receptor Antagonist
Author/Authors :
Cossy، Janine نويسنده , , Dechamps، Ingrid نويسنده , , Pardo، Domingo Gomez نويسنده , , Karoyan، Phillipe نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
An efficient enantioselective formal synthesis of Ro 67-8867 has been achieved in 7 steps using an amino-zinc-ene-enolate cyclization and an enantioselective ring enlargement of a substituted prolinol as the key steps.
Keywords :
asymmetric synthesis , amino-zinc-ene-enolate cyclization , ring expansion , piperidines , prolinol
