Title of article
Direct aldol condensation reaction of ethyl diazoacetate with trifluoromethyl ketones
Author/Authors
Han-Feng Cui، نويسنده , , Lian Wang، نويسنده , , Lijun Yang، نويسنده , , Jing Nie، نويسنده , , Yan Zheng، نويسنده , , Jun-An Ma، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
7
From page
8470
To page
8476
Abstract
An efficient and direct aldol-type condensation of ethyl diazoacetate with trifluoromethyl ketones was developed in the presence of dialkyl zinc. A series of trifluoromethylated products were obtained in good to excellent yields (60–95%). A preliminary extension to a catalytic enantioselective aldol reaction of ethyl diazoacetate to trifluoromethyl ketones (up to 72% ee) is also described.
Keywords
Aldol condensation , Enantioselectivity , Ethyl diazoacetate , Trifluoromethyl ketone
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103806
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