Author/Authors :
Iwao Okamoto، نويسنده , , Masayuki Terashima، نويسنده , , Hyuma Masu، نويسنده , , Mayumi Nabeta، نويسنده , , Kaori Ono، نويسنده , , Nobuyoshi Morita، نويسنده , , Kosuke Katagiri، نويسنده , , Isao Azumaya، نويسنده , , Osamu Tamura، نويسنده ,
Abstract :
A series of cis-preferential aromatic N-methyl amides was designed and synthesized, and acid-induced conformational alteration of these compounds was investigated by means of NMR measurements in solution and X-ray crystal structure analysis. Compounds with a terminal N-methyl-N-(2-pyridyl) amide unit showed acid-induced conformational change from cis to trans, while those with a terminal N-methyl-2-pyridinecarboxamide unit showed a change of the carbonyl orientation from anti to syn with retention of cis conformation.
Keywords :
Pyridine , foldamer , Molecular switch , Hydrogen bond , External stimulus responsive
