Author/Authors :
Aliasghar Jarrahpour، نويسنده , , Edris Ebrahimi، نويسنده , , Erik De Clercq، نويسنده , , Véronique Sinou، نويسنده , , Christine Latour، نويسنده , , Lamia Djouhri Bouktab، نويسنده , , Jean Michel Brunel، نويسنده ,
Abstract :
Some new mono-, bis-spiro- and dispiro-β-lactams have been synthesized from imines derived from 9H-fluoren-9-one and a ketene derived from 9H-xanthene-9-carboxylic acid or phenoxyacetic acid by a [2+2] cycloaddition reaction in good to excellent yields varying from 45 to 83%. The biological activity of these monocyclic β-lactams was successfully investigated against Plasmodium falciparum K14 resistant strain with excellent EC50 values up to 5 μM.
Keywords :
9H-Fluoren-9-one , 9H-Xanthene-9-carboxylic acid , Phenoxyacetic acid , Dispiro-?-lactams , Antimalarial activities
