Author/Authors :
Konstantin F. Suzdalev، نويسنده , , Sophia V. Den’kina، نويسنده , , Gennadii S. Borodkin، نويسنده , , Valerii V. Tkachev، نويسنده , , Mikhail A. Kiskin، نويسنده , , Mikhail E. Kletsky، نويسنده , , Oleg N. Burov، نويسنده ,
Abstract :
Reaction of 2-chloroindole-3-carbaldehyde with epibromohydrin gives the expected 1-(oxiran-2-ylmethyl) derivative. However the analogous reaction with epichlorohydrin leads to the formation of the oxazolo[3,2-a]indole skeleton. Some chemical properties of this tricyclic system were investigated. Its reaction with secondary amines unexpectedly proceeds with the opening of the oxazole ring.
Keywords :
Indoles , Aldehydes , Epihalogenohydrins , 2-a]indole
