Title of article
Studies on the radical addition reaction of perfluoroalkyl iodides with 2,3-allenols and the Pd-catalyzed kinetic resolution via Sonogashira coupling reaction
Author/Authors
Zhichao Ma، نويسنده , , Rong Zeng، نويسنده , , Chunling Fu، نويسنده , , Shengming Ma، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
11
From page
8808
To page
8818
Abstract
A radical addition reaction promoted by Na2S2O4 of perfluoroalkyl iodides with 2,3-allenols affording E/Z mixtures of 3-iodo-4-perfluoroalkyl-substituted allylic alcohols has been studied. Kinetic resolution with Sonogashira coupling reaction was applied to afford the Z isomer of 3-iodo-4-perfluoroalkyl-substituted allylic alcohol (Z-3) and the E isomer of conjugated enynic diols (E-5) in 39–52% and 22–40% yields, respectively.
Keywords
Allenol , Radical addition , Kinetic resolution
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103852
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