Author/Authors :
Jae-Hwan Kwak، نويسنده , , Young Ae Cho، نويسنده , , Jae-Yong Jang، نويسنده , , Seung-Yong Seo، نويسنده , , Heesoon Lee، نويسنده , , Jin Tae Hong، نويسنده , , Sang-Bae Han، نويسنده , , Kiho Lee، نويسنده , , Young-Shin Kwak، نويسنده , , Jae-Kyung Jung، نويسنده ,
Abstract :
Concise and practical synthesis of 4-O-methylhonokiol was achieved in 34% overall yield. The key features of our synthesis include chemoselective ortho-mono bromination of phenol as well as biaryl formation via Suzuki–Miyaura cross-coupling, in which bromophenol was reacted with potassium aryltrifluoroborate using Pd(OAc)2 and RuPhos under microwave conditions.
Keywords :
Potassium aryltrifluoroborate , Neolignan , Suzuki–Miyaura cross-coupling , 4-O-Methylhonokiol
