Author/Authors :
Stephen G. Davies، نويسنده , , Ai M. Fletcher، نويسنده , , Deri G. Hughes، نويسنده , , James A. Lee، نويسنده , , Paul D. Price، نويسنده , , Paul M. Roberts، نويسنده , , Angela J. Russell، نويسنده , , Andrew D. Smith، نويسنده , , James E. Thomson، نويسنده , , Oliver M.H. Williams، نويسنده ,
Abstract :
The conjugate addition of an enantiopure lithium amide to a ζ-hydroxy-α,β-unsaturated ester followed by a one-pot ring-closure/N-debenzylation protocol has been used in the asymmetric syntheses of (S)-coniine and (R)-δ-coniceine (isolated as the corresponding hydrochloride salts), and (R,R)-1-(hydroxymethyl)octahydroindolizine (the bicyclic fragment of stellettamides A–C).
Keywords :
lithium amide , Asymmetric synthesis , ?-Coniceine , Coniine , piperidines
