Title of article
Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors
Author/Authors
Jeffrey D. Winkler، نويسنده , , André K. Isaacs، نويسنده , , Chaomei Xiang، نويسنده , , Valérie Baubet، نويسنده , , Nadia Dahmane، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
6
From page
10261
To page
10266
Abstract
The design, synthesis, and biological evaluation of new analogs of the naturally occurring compound cyclopamine, a hedgehog signaling inhibitor, are described. Structure–activity relationship studies lead to an evolving model for the pharmacophore of this medically promising compound class of anti-cancer chemotherapeutic agents.
Keywords
Hedgehog signaling , Cancer chemotherapy , Structure–activity relationships , Cyclopamine , Steroidal alkaloid
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1104004
Link To Document