Title of article
Preparation of 6-aminoquinazolin-4(3H)-ones via direct SNAr on the quinazoline ring
Author/Authors
Bernard Barlaam، نويسنده , , Craig S. Harris، نويسنده , , Jonathan Lecoq، نويسنده , , Ha Thi Hoang Nguyen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
10
From page
534
To page
543
Abstract
The preparation of 6-aminoquinazolin-4(3H)-ones requires the use of platinum–metal group catalysis on the corresponding C-6-iodo or 6-bromo precursors. Herein, we report to our knowledge the first successful SNAr reaction directly at the unactivated C-6 position of the quinazolin-4(3H)-one nucleus.
Keywords
Unactivated fluorides , Quinazolin-4-(3H)-one , Direct SNAr
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104070
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