Title of article :
Defluorination–silylation of alkyl trifluoroacetates to 2,2-difluoro-2-(trimethylsilyl)acetates by copper-deposited magnesium and trimethylsilyl chloride
Author/Authors :
Shinya Utsumi، نويسنده , , Toshimasa Katagiri، نويسنده , , Kenji Uneyama، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
Reductive defluorination–silylation of alkyl trifluoroacetates with copper-deposited magnesium and trimethylsilyl chloride (TMS-Cl) gave 2,2-difluoro-2-(trimethylsilyl)acetates, potential difluoromethylene building blocks, in 60–68% yields.
Keywords :
Difluoromethylene building block , Reductive defluorination–silylation reaction from trifluoroaceates , Electron transfer , Reduction by magnesium metal , Copper-deposited magnesium
Journal title :
Tetrahedron
Journal title :
Tetrahedron
