Fulvynes, antimicrobial polyoxygenated acetylenes from the Mediterranean sponge Haliclona fulva

Nine linear polyoxygenated acetylenes, fulvynes A–I (1–9), exhibiting the uncommon 2-yne carboxylic acid functionality, have been isolated from the butanolic extract of the Mediterranean sponge Haliclona fulva. Their structures possess a long alkyl chain with several oxygenated carbons, and were established by detailed spectroscopic analysis. All fulvynes were found to be active against a chloramphenicol-resistant strain of Bacillus subtilis.