Title of article
Synthesis of CF3-containing tetrapeptide surrogates via Ugi reaction/dipolar cycloaddition sequence
Author/Authors
Daria V. Vorobyeva، نويسنده , , Nadezhda V. Sokolova، نويسنده , , Valentine G. Nenajdenko، نويسنده , , Alexander S. Peregudov، نويسنده , , Sergey N. Osipov، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
6
From page
872
To page
877
Abstract
A convenient synthetic pathway to novel functionalized tetrapeptides containing the 1,2,3-triazole moiety is described. The target molecules were obtained by the reaction of fluorinated α-amino acids or α-aminophosphonates with azidopeptides via Cu(I)-catalyzed Huisgen cycloaddition reaction (click chemistry). The synthesized tetrapeptides may find important applications in biomedical chemistry as potential drugs.
Keywords
Azidopeptides , Tetrapeptides , ?-Trifluoromethyl-?-amino acids , ?-Aminophosphonates , Click chemistry
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104114
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