Title of article :
Synthesis of (−)-benzolactam-V8 by application of asymmetric aziridination
Author/Authors :
Itsara Khantikaew، نويسنده , , Masato Takahashi، نويسنده , , Takuya Kumamoto، نويسنده , , Noriyuki Suzuki، نويسنده , , Tsutomu Ishikawa، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
(−)-Benzolactam-V8, an artificially-designed cyclic dipeptide with strong tumor-promoter activity, was synthesized from benzyl (S)-N-(2-formylphenyl)-N-methylvalinate by application of guanidinium ylide-participated asymmetric aziridination followed by the reductive ring-opening reaction of 3-arylaziridine-2-carboxylate formed.
Keywords :
3-Arylaziridine-2-carboxylate , ring-opening reaction , (?)-Benzolactam-V8 , Asymmetric synthesis , Guanidinium ylide
Journal title :
Tetrahedron
Journal title :
Tetrahedron
