Author/Authors :
Aiping Huang، نويسنده , , Zhi Qiao، نويسنده , , Xinhai Zhang، نويسنده , , Wei Yu، نويسنده , , Qingqing Zheng، نويسنده , , Ying Ma، نويسنده , , Chen Ma، نويسنده ,
Abstract :
A transition metal-free tandem process for the synthesis of pyrrolopyrazino[2,3-d]pyridazine-diones is described. The process is an efficient construction of this tricyclic system by a one-pot coupling/Smiles rearrangement/cyclization approach. This methodology has potential applications in the synthesis of biologically and medicinally relevant compounds.
Keywords :
3-d]pyridazine-dione , Smiles rearrangement , Tandem reaction , Synthesis , X-Ray crystallographic analysis
