Title of article
A Flexible Carbanionic Approach to Protected trans-(2R,3S)-2-Substituted 3-Aminopyrrolidines: Application to the Asymmetric Synthesis of (+)-Absouline
Author/Authors
Tang، Tian نويسنده , , Ruan، Yuan-Ping نويسنده , , Ye، Jian-Liang نويسنده , , Huang، Pei-Qiang نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-230
From page
231
To page
0
Abstract
Based on the use of phenyl thioether (3S)-7 as a synthetic equivalent to the N- and (alpha)-dianions (3S)-2a, a new carbanionic approach to trans-(2R,3S)-2-substituted 3-aminopyrrolidines (10) is described. Application of the method to the asymmetric synthesis of 1-aminopyrrolizidine alkaloid (+)-absouline is also reported.
Keywords
pyrrolidine , Carbanions , reductive lithiation , additions , asymmetric synthesis
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110412
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