Title of article :
Concise synthesis of new bridged-nicotine analogues
Author/Authors :
François Crestey، نويسنده , , Geert Hooyberghs، نويسنده , , Jesper L. Kristensen، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.
Keywords :
Pyridine metallation , Bridged-nicotine analogue , Suzuki–Miyaura cross-coupling reaction , Nicotinic acetylcholine receptor , Intramolecular reductive amination
Journal title :
Tetrahedron
Journal title :
Tetrahedron
