Author/Authors :
Marc Schumacher، نويسنده , , Neil Wilson، نويسنده , , Jioji N. Tabudravu، نويسنده , , Christine Edwards، نويسنده , , Linda A. Lawton، نويسنده , , Cherie Motti، نويسنده , , Anthony D. Wright، نويسنده , , Marc Diederich، نويسنده , , Marcel Jaspars، نويسنده ,
Abstract :
Investigation of aqueous methanol extracts of the cyanobacterium Nodularia spumigena KAC 66 led to the isolation of the nodulopeptins 899, 901 and 917. The chemical structures were determined using high-resolution NMR and MS-data. The stereochemistry of the amino-acid residues was realized by LC–MS analysis using Marfey’s reagent. The bioactivity of the novel compounds was determined.
Keywords :
Spectroscopy , NF-?B , Peptides , Cyanobacteria , Polypeptides , Structure determination
