Preparation of N-(p-Tolyl)azacalix[n](2,6)pyridines Constructed of Various Numbers of the Recurring Unit

Synthetic routes for N-(p-tolyl)-substituted azacalix[n](2,6)pyridines via Cu- and Pd-catalyzed aryl amination reactions have been elaborated, and the macrocycles constructed of various numbers (n = 3-8, and 10) of a N-(p-tolyl)aminopyridine recurring unit have been isolated. A cyclic trimer 1 was obtained in good yield. Molecular structures of some macrocycles and a Cu(I) complex of 1 were determined by X-ray crystallography.