Title of article
Synthetic receptor and its association with CTD peptides
Author/Authors
Saihui Zhang، نويسنده , , Liang Han، نويسنده , , Chuan-guang Li، نويسنده , , Jun Wang، نويسنده , , Wei Wang، نويسنده , , Zhi Yuan، نويسنده , , Xueping Gao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
6
From page
2357
To page
2362
Abstract
In this study, a receptor for phosphorylated peptide was developed. The receptor contains Zn2+–dipicolylamine (Zn–Dpa) moiety at one end and guanidiniocarbonyl pyrrole at the other. The association between the receptor and CTD (carboxy-terminal domain of RNA polymerase II) peptides with different phosphorylated patterns was investigated by isothermal titration calorimetry and molecular docking, and the receptor showed much higher affinity towards bis-phosphorylated CTD peptide with affinity constant K=1.09×105.
Keywords
Artificial receptor , Phosphorylated peptides , CTD peptides , Isothermal titration calorimetry
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104288
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