Solid-Phase Synthesis of Disubstituted 1,3-Dihydro-2H-imidazol-2-ones

An efficient and straightforward solid-phase synthesis of sulfonylimidazolones 2a-g is described. Our design was directed toward obtaining molecules for a general library development and incorporates functionalities that fulfill lead-like criteria. The synthesis was realized with the use of SPOS in fair to good yields and purity. Monitoring and quantitation of intermediates and final products were performed by the use of LCMS and NMR spectroscopy.