Author/Authors :
Kaori Hayashi، نويسنده , , Tominari Choshi، نويسنده , , Kyoko Chikaraishi، نويسنده , , Aimi Oda، نويسنده , , Rikako Yoshinaga، نويسنده , , Noriyuki Hatae، نويسنده , , Minoru Ishikura، نويسنده , , Satoshi Hibino، نويسنده ,
Abstract :
A new entry to the total synthesis of isocryptolepine (cryptosanguinolentine), isolated from Cryptolepis sanguinolenta, was achieved by constructing a tetracyclic ring system through a microwave-assisted tandem Curtius rearrangement and electrocyclic reaction of an aza 6π-electron system. The tetracyclic lactam was converted to isocryptolepine in a four-step sequence.
