Author/Authors :
Aliasghar Jarrahpour، نويسنده , , Edris Ebrahimi، نويسنده , , Reza Khalifeh، نويسنده , , Hashem Sharghi، نويسنده , , Mohammad Sahraei، نويسنده , , Véronique Sinou، نويسنده , , Christine Latour، نويسنده , , Jean Michel Brunel، نويسنده ,
Abstract :
A novel series of β-lactams bearing an anthraquinone moiety have been synthesized from imines derived from anthraquinone-2-carbaldehyde and ketenes by a [2+2] cycloaddition reaction. The cycloadducts were fully characterized and evaluated for their antimalarial activities against Plasmodium falciparum K14 resistant strain and showed moderate to excellent EC50 values varying from 9 to 50 μM.
Keywords :
?-lactam , Anthraquinone-2-carbaldehyde , Tosyl chloride , Plasmodium falciparum , antimalarial activity
