Nucleophilic difluoromethylation of Cdouble bond; length as m-dashN bonds in heterocycles with difluoromethyl silane reagents

An efficient and straightforward nucleophilic difluoromethylation of Cdouble bond; length as m-dashN bonds in heterocycles under the activation of alkylating agents has been developed. Cyclic iminium salts derived from dihydroisoquinolines, quinolines, and pyridines were successfully difluoromethylated with sulfur-based fluoroalkyl silanes affording a series of new difluoromethylated nitrogen-containing heterocyclic compounds.