Title of article
A Convergent Enantioselective Synthesis of the Anti-Malarial Agent (+)-Febrifugine
Author/Authors
Ashoorzadeh، Amir نويسنده , , Caprio، Vittorio نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-345
From page
346
To page
0
Abstract
Chiral pool derived 3-benzyloxy-3,4,5,6-tetrahydropyridine N-oxide underwent regio- and diastereoselective 1,3-dipolar cycloaddition with N-allylquinazolone to give a cycloadduct that was elaborated to (+)-febrifugine a potent anti-malarial alkaloid.
Keywords
Alkaloids , piperidines , nitrones , Cycloadditions , reductive ring-opening
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110474
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