Title of article :
A Convergent Enantioselective Synthesis of the Anti-Malarial Agent (+)-Febrifugine
Author/Authors :
Ashoorzadeh، Amir نويسنده , , Caprio، Vittorio نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Chiral pool derived 3-benzyloxy-3,4,5,6-tetrahydropyridine N-oxide underwent regio- and diastereoselective 1,3-dipolar cycloaddition with N-allylquinazolone to give a cycloadduct that was elaborated to (+)-febrifugine a potent anti-malarial alkaloid.
Keywords :
Alkaloids , piperidines , nitrones , Cycloadditions , reductive ring-opening
