Synthesis of optically active medium-sized α-aminolactams via ring-closing metathesis

The synthesis of optically active medium-sized α-aminolactams via ring-closing metathesis is described. The amidation of optically active N-Boc-allylglycine derivatives with N-protected alkenylamine, and ring-closing metathesis resulted in the formation of medium-sized α-aminolactams with good yield.