Author/Authors :
Karel Piron، نويسنده , , Sara Kenis، نويسنده , , Guido Verniest، نويسنده , , Riccardo Surmont، نويسنده , , Jan Willem Thuring، نويسنده , , Peter ten Holte، نويسنده , , Frederik Deroose، نويسنده , , Norbert De Kimpe، نويسنده ,
Abstract :
A synthetic route toward new 8,8-difluoro-1,6-naphthyridine-5,7-diones, which are of interest as new building blocks in pharmaceutical chemistry, is described. The key steps include a copper-mediated cross-coupling of ethyl bromodifluoroacetate and 2-bromo-3-cyanopyridine, followed by hydrolysis of the nitrile function and subsequent cyclization.
