Title of article
Synthesis of gem-difluorinated 1,6-naphthyridine-5,7-diones
Author/Authors
Karel Piron، نويسنده , , Sara Kenis، نويسنده , , Guido Verniest، نويسنده , , Riccardo Surmont، نويسنده , , Jan Willem Thuring، نويسنده , , Peter ten Holte، نويسنده , , Frederik Deroose، نويسنده , , Norbert De Kimpe، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
7
From page
6941
To page
6947
Abstract
A synthetic route toward new 8,8-difluoro-1,6-naphthyridine-5,7-diones, which are of interest as new building blocks in pharmaceutical chemistry, is described. The key steps include a copper-mediated cross-coupling of ethyl bromodifluoroacetate and 2-bromo-3-cyanopyridine, followed by hydrolysis of the nitrile function and subsequent cyclization.
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104825
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