Novel and efficient synthesis of substituted quinoline-1-oxides and the complex compounds SnL2Cl2 (L=2-aminoquinoline-1-oxides) with the aid of stannous chloride

A novel and efficient approach to the synthesis of substituted quinoline-1-oxides and the complex compounds SnL2Cl2 (L=2-aminoquinoline-1-oxides) was developed. The reaction has fancy selectivity when 3-(2-nitrophenyl)acrylonitriles were treated with the aid of SnCl2 reagent under the same conditions. When R is –CN or –COOR′ the complex compounds SnL2Cl2 (L=2-aminoquinoline-1-oxides) were obtained. Whereas, when R is H or aryl another series of substituted quinoline-1-oxides were formed. The products have been screened for their anticancer activities.