Author/Authors :
Qian Zhang، نويسنده , , Gang Cheng، نويسنده , , Yong-Zhen Huang، نويسنده , , Guirong Qu، نويسنده , , Hong-Ying Niu، نويسنده , , Hai-Ming Guo، نويسنده ,
Abstract :
Under the assistance of β-cyclodextrin, purine was effectively alkylated at N9 together with up to 99% conversion and good to excellent yield using water as the solvent. High regioselectivity-N9/N7 selectivity>99:1 was attributed to the β-cyclodextrin cavity blocked the N7 of purines ring.
Keywords :
Purine , Alkylation , Selectivity , ?-Cyclodextrin
